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2021-02-08T14:55:34+05:30
2021-02-08T14:47:22+05:30
2021-02-08T14:55:34+05:30
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(tl)Tj
0 Tc 0 Tw (y)Tj
1.043 0 Td
( )Tj
-0.005 Tc 0.005 Tw 0.246 0 Td
(und)Tj
0 Tc 0 Tw (e)Tj
1.925 0 Td
(r)Tj
-0.005 Tc 0.005 Tw 0.31 0 Td
(go)Tj
0 Tc 0 Tw (i)Tj
-0.005 Tc 0.005 Tw 1.264 0 Td
(ng)Tj
-0.004 Tc 0 Tw ( cli)Tj
0 Tc (n)Tj
-0.004 Tc 2.718 0 Td
(ical t)Tj
0 Tc (r)Tj
-0.004 Tc 0.004 Tw 2.275 0 Td
(ial)Tj
0 Tc 0 Tw (s)Tj
1.372 0 Td
(,)Tj
-0.005 Tw 0.246 0 Td
( D)Tj
0 Tw 0.962 0 Td
(r)Tj
-0.004 Tc 0.273 0 Td
(. Zl)Tj
0 Tc (o)Tj
1.868 0 Td
(t)Tj
0.274 0 Td
(y)Tj
0.495 0 Td
( )Tj
0.246 0 Td
(s)Tj
-0.004 Tc 0.004 Tw 0.384 0 Td
(ai)Tj
0 Tc 0 Tw (d)Tj
1.209 0 Td
(.)Tj
-20.539 -1.2 Td
(\223)Tj
0.44 0 Td
(I)Tj
-0.004 Tc 0.328 0 Td
( am )Tj
0 Tc (p)Tj
2.201 0 Td
(a)Tj
0.44 0 Td
(r)Tj
-0.004 Tc 0.004 Tw 0.328 0 Td
(t )Tj
-0.005 Tc 0.005 Tw 0.52 0 Td
(of)Tj
0 Tc -0.004 Tw ( t)Tj
0 Tw 1.343 0 Td
(h)Tj
-0.004 Tc 0.495 0 Td
(at t)Tj
0 Tc (r)Tj
-0.004 Tc 1.562 0 Td
(ial, a)Tj
-0.005 Tc 0.005 Tw (nd)Tj
0 Tc 0 Tw ( )Tj
3.155 0 Td
(w)Tj
-0.004 Tc 0.717 0 Td
(e a)Tj
0 Tc (r)Tj
-0.004 Tc 1.454 0 Td
(e t)Tj
-0.005 Tc 0.005 Tw (ry)Tj
0 Tc 0 Tw (i)Tj
-0.005 Tc 0.005 Tw 2.057 0 Td
(ng)Tj
0 Tc -0.004 Tw ( t)Tj
0 Tw 1.51 0 Td
(o)Tj
0.495 0 Td
( )Tj
0.246 0 Td
(s)Tj
-0.004 Tc 0.384 0 Td
(ee i)Tj
0 Tc (f)Tj
1.728 0 Td
( )Tj
0.246 0 Td
(a)Tj
-19.647 -1.2 Td
(d)Tj
-0.004 Tc 0.004 Tw 0.495 0 Td
(ail)Tj
0 Tc 0 Tw (y)Tj
-0.004 Tw 1.483 0 Td
( t)Tj
-0.005 Tc 0.005 Tw 0.52 0 Td
(op)Tj
-0.004 Tc 0 Tw (ical a)Tj
-0.005 Tc 0.005 Tw (pp)Tj
ET
BT
-0.004 Tc 0.004 Tw 10 0 0 10 102.541 557.8403 Tm
(licati)Tj
-0.005 Tc 0.005 Tw (on)Tj
0 Tc 0 Tw ( )Tj
-0.005 Tc 0.005 Tw 3.211 0 Td
(of)Tj
0 Tc -0.004 Tw ( t)Tj
0 Tw 1.343 0 Td
(h)Tj
0.495 0 Td
(i)Tj
0.274 0 Td
(s)Tj
-0.004 Tw 0.384 0 Td
( a)Tj
0 Tw 0.686 0 Td
(g)Tj
0.495 0 Td
(e)Tj
0.44 0 Td
(n)Tj
-0.004 Tc 0.004 Tw 0.495 0 Td
(t )Tj
0 Tc 0 Tw 0.52 0 Td
(w)Tj
-0.004 Tc 0.004 Tw 0.717 0 Td
(ill )Tj
0 Tc 0 Tw 1.067 0 Td
(r)Tj
0.328 0 Td
(e)Tj
-0.005 Tc 0.005 Tw 0.44 0 Td
(du)Tj
-0.004 Tc 0.004 Tw (ce )Tj
0 Tc 0 Tw 2.116 0 Td
(f)Tj
0.328 0 Td
(a)Tj
0.44 0 Td
(-)Tj
-0.004 Tc -20.369 -1.2 Td
(cial BC)Tj
0 Tc (C)Tj
3.661 0 Td
( )Tj
-0.005 Tc 0.005 Tw 0.246 0 Td
(burd)Tj
0 Tc 0 Tw (e)Tj
2.253 0 Td
(n)Tj
-0.004 Tw 0.495 0 Td
( i)Tj
0 Tw 0.52 0 Td
(n)Tj
0.495 0 Td
( )Tj
0.246 0 Td
(b)Tj
0.495 0 Td
(a)Tj
0.44 0 Td
(s)Tj
-0.004 Tc 0.384 0 Td
(al cell )Tj
0 Tc (n)Tj
3.128 0 Td
(e)Tj
-0.005 Tc 0.44 0 Td
(vus syndro)Tj
-0.004 Tc 0.004 Tw (me )Tj
0 Tc 0 Tw 5.771 0 Td
(p)Tj
0.495 0 Td
(a)Tj
0.44 0 Td
(-)Tj
-0.004 Tc 0.004 Tw -19.509 -1.2 Td
(tie)Tj
0 Tc 0 Tw (n)Tj
1.483 0 Td
(t)Tj
0.274 0 Td
(s)Tj
-0.004 Tc 0.004 Tw 0.384 0 Td
(. )Tj
-0.005 Tc 0.005 Tw 0.492 0 Td
(So)Tj
-0.004 Tc 0.004 Tw (me)Tj
0 Tc 0 Tw ( )Tj
-0.004 Tc 0.004 Tw 2.505 0 Td
(ea)Tj
0 Tc 0 Tw (r)Tj
1.208 0 Td
(l)Tj
0.274 0 Td
(y)Tj
0.495 0 Td
( )Tj
0.246 0 Td
(s)Tj
-0.004 Tc 0.004 Tw 0.384 0 Td
(mall )Tj
0 Tc 0 Tw 2.007 0 Td
(s)Tj
0.384 0 Td
(t)Tj
-0.005 Tc 0.005 Tw 0.274 0 Td
(ud)Tj
-0.004 Tc 0.004 Tw (ie)Tj
0 Tc 0 Tw (s)Tj
-0.004 Tw 2.088 0 Td
( a)Tj
-0.005 Tc 0.005 Tw 0.686 0 Td
(nd)Tj
0 Tc 0 Tw ( )Tj
-0.005 Tc 0.005 Tw 1.236 0 Td
(pr)Tj
-0.004 Tc 0.004 Tw (elimi)Tj
0 Tc 0 Tw (n)Tj
3.353 0 Td
(a)Tj
0.44 0 Td
(r)Tj
0.328 0 Td
(y)Tj
-18.54 -1.2 Td
(e)Tj
0.44 0 Td
(v)Tj
0.495 0 Td
(i)Tj
0.274 0 Td
(d)Tj
0.495 0 Td
(e)Tj
0.44 0 Td
(n)Tj
-0.004 Tc 0.004 Tw 0.495 0 Td
(ce )Tj
-0.005 Tc 0.005 Tw 1.126 0 Td
(sugg)Tj
0 Tc 0 Tw (e)Tj
2.309 0 Td
(s)Tj
-0.004 Tc 0.004 Tw 0.384 0 Td
(te)Tj
0 Tc 0 Tw (d)Tj
-0.004 Tc 1.209 0 Td
( it )Tj
-0.005 Tc 0.005 Tw (prob)Tj
0 Tc 0 Tw (a)Tj
3.292 0 Td
(b)Tj
0.495 0 Td
(l)Tj
-0.005 Tc 0.005 Tw 0.274 0 Td
(y )Tj
0 Tc 0 Tw 0.74 0 Td
(i)Tj
0.274 0 Td
(s)Tj
-0.004 Tw 0.384 0 Td
( e)Tj
0 Tw 0.686 0 Td
(f)Tj
0.31 0 Td
(f)Tj
-0.004 Tc 0.004 Tw 0.328 0 Td
(ecti)Tj
0 Tc 0 Tw (v)Tj
-0.004 Tc 0.004 Tw 1.922 0 Td
(e.\224 )Tj
0 Tc 0 Tw 1.372 0 Td
( )Tj
-15.943 -1.2 Td
(As the biochemistry on these agents is refined)Tj
-1.8 -1.2 Td
(during the next 10 to 20 years, topical hedgehog in-)Tj
0 -1.2 Td
(hibitors will likely play an impactful role in BCC)Tj
0 -1.2 Td
(treatment, he said. )Tj
1.8 -1.2 Td
(Systemic hedgehog inhibitors are also under)Tj
-1.8 -1.2 Td
(study in BCC treatment, D)Tj
10.694 0 Td
(r)Tj
0.278 0 Td
(. Zloty said, including)Tj
-10.972 -1.2 Td
(the oral agent vismodegib. In particula)Tj
15.439 0 Td
(r)Tj
0.293 0 Td
(, di)Tj
(f)Tj
1.593 0 Td
(ferent)Tj
-17.325 -1.2 Td
(dosing regimens are being researched to reduce side)Tj
0 -1.2 Td
(e)Tj
(f)Tj
0.759 0 Td
(fects while maintaining e)Tj
10.08 0 Td
(f)Tj
0.315 0 Td
(ficac)Tj
1.942 0 Td
(y)Tj
0.436 0 Td
(. )Tj
-11.732 -1.2 Td
(PD-1 inhibitors are being investigated for squa-)Tj
-1.8 -1.2 Td
(mous cell carcinomas \(SCCs\), he said. One, cemi-)Tj
0 -1.2 Td
(plimab, was approved in Canada in 2019 to treat)Tj
0 -1.2 Td
(locally advanced or metastatic SCCs.)Tj
14.913 0 Td
( )Tj
0.232 0 Td
(While the re-)Tj
-15.145 -1.2 Td
(sponse rate to cemiplimab is less than 50 per cent,)Tj
0 -1.2 Td
(and the complete response rate is only five to 10 per)Tj
0 -1.2 Td
(cent, D)Tj
(r)Tj
3.166 0 Td
(. Zloty said that patients could experience a)Tj
20.13 52.884 Td
(noticeable)Tj
4.109 0 Td
( difference)Tj
4.302 0 Td
( even with only a partial )Tj
-8.411 -1.188 Td
(response im-provement in their quality of life. )Tj
1.8 -1.212 Td
(More therapeutic agents that work through the)Tj
18.55 0 Td
( )Tj
-20.35 -1.2 Td
(same immune pathway as PD-1 inhibitors will)Tj
18.554 0 Td
( )Tj
-18.554 -1.188 Td
(likely be developed, D)Tj
9.053 0 Td
(r)Tj
0.278 0 Td
(. Zloty said, and will proba-)Tj
-9.331 -1.212 Td
(bly have positive e)Tj
7.526 0 Td
(f)Tj
0.315 0 Td
(fects on the treatment of both)Tj
11.746 0 Td
( )Tj
-19.587 -1.2 Td
(SCCs and Merkel cell carcinomas. He noted that)Tj
19.495 0 Td
( )Tj
-19.494 -1.188 Td
(there has been early research into using PD-1 in-)Tj
0 -1.212 Td
(hibitors for BCCs in patients who have failed on)Tj
19.387 0 Td
( )Tj
-19.387 -1.188 Td
(sonic hedgehog inhibitors. )Tj
1.8 -1.212 Td
(Di)Tj
(f)Tj
1.315 0 Td
(ferent dosing regimens of PD-1 inhibitors)Tj
16.692 0 Td
( )Tj
-19.807 -1.2 Td
(are also being explored, he said, noting that even if)Tj
20.407 0 Td
( )Tj
-20.407 -1.188 Td
(less-frequent dosing did not impact side-e)Tj
16.746 0 Td
(f)Tj
0.315 0 Td
(fect pro-)Tj
-17.061 -1.212 Td
(files, if e)Tj
3.526 0 Td
(f)Tj
0.315 0 Td
(ficacy can be maintained, it is beneficial)Tj
16.134 0 Td
( )Tj
-19.975 -1.188 Td
(to patients to need fewer trips into clinic\227espe-)Tj
0 -1.2 Td
(cially for patients who travel long distances. )Tj
1.8 -1.212 Td
(Other potential treatments that D)Tj
13.163 0 Td
(r)Tj
0.278 0 Td
(. Zloty said)Tj
( )Tj
-15.241 -1.188 Td
(are in early research stages include: )Tj
1.8 -1.2 Td
(l)Tj
0.264 0 Td
(o)Tj
-0.014 Tc 0.014 Tw 0.485 0 Td
(cal)Tj
0 Tc 0 Tw ( )Tj
-0.014 Tc 0.014 Tw 1.358 0 Td
(la)Tj
0 Tc 0 Tw (s)Tj
1.068 0 Td
(e)Tj
0.43 0 Td
(r)Tj
0.298 0 Td
(-)Tj
0.318 0 Td
(t)Tj
0.264 0 Td
(h)Tj
0.485 0 Td
(e)Tj
0.43 0 Td
(r)Tj
-0.014 Tc 0.014 Tw 0.318 0 Td
(mal)Tj
0 Tc 0 Tw ( )Tj
1.692 0 Td
(m)Tj
-0.015 Tc 0.015 Tw 0.764 0 Td
(odu)Tj
-0.014 Tc 0.014 Tw (lati)Tj
-0.015 Tc 0.015 Tw (on )Tj
0 Tc 0 Tw 3.881 0 Td
(t)Tj
0.264 0 Td
(r)Tj
-0.014 Tc 0.014 Tw 0.318 0 Td
(eatme)Tj
0 Tc 0 Tw (n)Tj
2.802 0 Td
(t)Tj
-0.015 Tc 0.264 0 Td
(s, wh)Tj
0 Tc (e)Tj
2.466 0 Td
(r)Tj
0.318 0 Td
(e)Tj
-20.288 0 Td
(\225)Tj
1.8 -1.2 Td
(a)Tj
-0.015 Tc 0.015 Tw 0.43 0 Td
(n )Tj
0 Tc 0 Tw 0.72 0 Td
(a)Tj
0.43 0 Td
(g)Tj
0.485 0 Td
(e)Tj
0.43 0 Td
(n)Tj
0.485 0 Td
(t)Tj
-0.015 Tc 0.264 0 Td
( wh)Tj
-0.014 Tc 0.014 Tw (ic)Tj
-0.015 Tc 0 Tw (h b)Tj
-0.014 Tc 0.014 Tw (ec)Tj
0 Tc 0 Tw (o)Tj
-0.014 Tc 0.014 Tw 4.671 0 Td
(me)Tj
-0.015 Tc 0 Tw (s ho)Tj
-0.014 Tc 0.014 Tw (t )Tj
-0.015 Tc 0.015 Tw 3.273 0 Td
(wh)Tj
0 Tc 0 Tw (e)Tj
-0.015 Tc 0.015 Tw 1.622 0 Td
(n )Tj
0 Tc 0 Tw 0.72 0 Td
(i)Tj
-0.015 Tc 0.015 Tw 0.264 0 Td
(rr)Tj
0 Tc 0 Tw (a)Tj
1.066 0 Td
(d)Tj
-0.014 Tc 0.014 Tw 0.485 0 Td
(iate)Tj
0 Tc 0 Tw (d)Tj
-15.343 -1.2 Td
(w)Tj
-0.014 Tc 0.014 Tw 0.707 0 Td
(it)Tj
-0.015 Tc 0.015 Tw (h )Tj
-0.014 Tc 0 Tw 1.248 0 Td
(a la)Tj
0 Tc (s)Tj
1.734 0 Td
(e)Tj
-0.015 Tc 0.015 Tw 0.43 0 Td
(r )Tj
0 Tc 0 Tw 0.553 0 Td
(i)Tj
-0.015 Tc 0.015 Tw 0.264 0 Td
(s )Tj
0 Tc 0 Tw 0.609 0 Td
(a)Tj
-0.015 Tc 0.015 Tw 0.43 0 Td
(pp)Tj
-0.014 Tc 0.014 Tw (lie)Tj
-0.015 Tc 0.015 Tw (d )Tj
0 Tc 0 Tw 2.647 0 Td
(t)Tj
-0.015 Tc 0.015 Tw 0.264 0 Td
(o )Tj
0 Tc 0 Tw 0.72 0 Td
(t)Tj
0.264 0 Td
(h)Tj
0.485 0 Td
(e)Tj
-0.015 Tc 0.43 0 Td
( surf)Tj
-0.014 Tc 0.014 Tw (ace)Tj
-0.015 Tc 0 Tw ( of )Tj
0 Tc (a)Tj
4.723 0 Td
( )Tj
-0.014 Tc 0.014 Tw 0.235 0 Td
(le)Tj
0 Tc 0 Tw (s)Tj
1.068 0 Td
(i)Tj
-0.015 Tc 0.015 Tw 0.264 0 Td
(on)Tj
0 Tc 0 Tw (;)Tj
-17.073 -1.2 Td
(adjuvant radiotherapy for SCCs with perineural)Tj
-1.8 0 Td
(\225)Tj
1.8 -1.2 Td
(involvement;)Tj
0 -1.2 Td
(intra-lesional injections of the HP)Tj
13.497 0 Td
(V)Tj
0.704 0 Td
( vaccine.)Tj
-16.001 0 Td
(\225)Tj
0 -1.2 Td
(That last approach, because of its relatively benign)Tj
0 -1.2 Td
(nature, could be of particular benefit to patients)Tj
0 -1.2 Td
(with multiple SCCs, or senior patients with como)Tj
19.777 0 Td
(r)Tj
0.313 0 Td
(-)Tj
-20.09 -1.2 Td
(bidities that would preclude radiation or su)Tj
17.163 0 Td
(r)Tj
0.315 0 Td
(gical)Tj
-17.478 -1.2 Td
(treatment, he said. Howeve)Tj
10.913 0 Td
(r)Tj
0.293 0 Td
(, there has so far been)Tj
-11.206 -1.2 Td
(limited research on this approach, D)Tj
14.495 0 Td
(r)Tj
0.278 0 Td
(. Zloty said,)Tj
-14.773 -1.2 Td
(and it is not clear if it is the HP)Tj
12.47 0 Td
(V)Tj
0.704 0 Td
( vaccine compo-)Tj
-13.174 -1.2 Td
(nent itself having an e)Tj
8.831 0 Td
(f)Tj
0.315 0 Td
(fect or only a local immune)Tj
-9.146 -1.2 Td
(response to the aluminum adjuvant.)Tj
/T1_0 1 Tf
0 -2.466 Td
(Actinic keratosis )Tj
/TT2 1 Tf
0 -1.134 Td
(One area of)Tj
( )Tj
4.859 0 Td
(AK treatment where there is room for)Tj
-4.859 -1.2 Td
(improvement is the e)Tj
8.415 0 Td
(f)Tj
0.315 0 Td
(ficacy of field therap)Tj
8.356 0 Td
(y)Tj
0.435 0 Td
(, said)Tj
/T1_0 1 Tf
-17.521 -1.266 Td
(D)Tj
(r)Tj
0.901 0 Td
(. Marie-Mich\350le Blouin)Tj
/TT2 1 Tf
9.518 0 Td
(, a dermatologist in prac-)Tj
-10.419 -1.134 Td
(tice at Centre Hospitalier Universitaire de Qu\351bec)Tj
0 -1.2 Td
(\(CHU de Qu\351bec\), with sub-specializations in)Tj
0 -1.2 Td
(Mohs micrographic su)Tj
8.999 0 Td
(r)Tj
0.315 0 Td
(gery and skin oncolog)Tj
8.859 0 Td
(y)Tj
0.435 0 Td
(. )Tj
-16.808 -1.2 Td
(W)Tj
0.93 0 Td
(h)Tj
-0.014 Tc 0.014 Tw 0.485 0 Td
(ile)Tj
0 Tc -0.015 Tw ( f)Tj
-0.014 Tc 0.014 Tw 1.511 0 Td
(iel)Tj
-0.015 Tc 0.015 Tw (d )Tj
0 Tc 0 Tw 1.677 0 Td
(t)Tj
0.264 0 Td
(h)Tj
0.485 0 Td
(e)Tj
0.43 0 Td
(r)Tj
0.318 0 Td
(a)Tj
0.43 0 Td
(p)Tj
-0.014 Tc 0.014 Tw 0.485 0 Td
(ie)Tj
-0.015 Tc 0 Tw (s h)Tj
0 Tc (a)Tj
2.218 0 Td
(v)Tj
0.485 0 Td
(e)Tj
0.43 0 Td
( )Tj
-0.014 Tc 0.014 Tw 0.235 0 Td
(a )Tj
-0.015 Tc 0 Tw 0.666 0 Td
(70 p)Tj
0 Tc (e)Tj
-0.015 Tc 0.015 Tw 2.12 0 Td
(r )Tj
-0.014 Tc 0.014 Tw 0.553 0 Td
(ce)Tj
0 Tc 0 Tw (n)Tj
1.345 0 Td
(t)Tj
-0.015 Tw 0.264 0 Td
( r)Tj
0 Tw 0.553 0 Td
(e)Tj
-0.015 Tc 0.015 Tw 0.43 0 Td
(spons)Tj
0 Tc 0 Tw (e)Tj
-18.112 -1.2 Td
(r)Tj
-0.014 Tc 0.014 Tw 0.318 0 Td
(ate)Tj
0 Tc 0 Tw (,)Tj
1.359 0 Td
( )Tj
0.236 0 Td
(r)Tj
-0.014 Tc 0.014 Tw 0.318 0 Td
(ate)Tj
-0.015 Tc 0 Tw (s of r)Tj
0 Tc (e)Tj
3.519 0 Td
(o)Tj
-0.014 Tc 0.014 Tw 0.485 0 Td
(cc)Tj
-0.015 Tc 0.015 Tw (urr)Tj
0 Tc 0 Tw (e)Tj
2.411 0 Td
(n)Tj
-0.014 Tc 0.014 Tw 0.485 0 Td
(ce)Tj
0 Tc 0 Tw ( )Tj
1.095 0 Td
(a)Tj
0.43 0 Td
(r)Tj
-0.014 Tc 0.014 Tw 0.318 0 Td
(e )Tj
0 Tc 0 Tw 0.666 0 Td
(h)Tj
0.485 0 Td
(i)Tj
-0.015 Tc 0.264 0 Td
(gh, sh)Tj
0 Tc (e)Tj
-0.015 Tw 2.729 0 Td
( s)Tj
-0.014 Tc 0.014 Tw 0.609 0 Td
(ai)Tj
-0.015 Tc 0 Tw (d, s)Tj
0 Tc (o)Tj
-15.725 -1.2 Td
(a)Tj
0.43 0 Td
(g)Tj
0.485 0 Td
(e)Tj
0.43 0 Td
(n)Tj
0.485 0 Td
(t)Tj
0.264 0 Td
(s)Tj
-0.014 Tw 0.374 0 Td
( t)Tj
0 Tw 0.5 0 Td
(h)Tj
-0.014 Tc 0.014 Tw 0.485 0 Td
(at )Tj
-0.015 Tc 0.015 Tw 0.93 0 Td
(produ)Tj
-0.014 Tc 0.014 Tw (ce)Tj
0 Tc 0 Tw ( )Tj
3.353 0 Td
(l)Tj
-0.015 Tc 0.015 Tw 0.264 0 Td
(ong)Tj
0 Tc 0 Tw (e)Tj
1.885 0 Td
(r)Tj
0.298 0 Td
(-)Tj
-0.014 Tc 0.014 Tw 0.318 0 Td
(la)Tj
0 Tc 0 Tw (s)Tj
-0.014 Tc 0.014 Tw 1.068 0 Td
(ti)Tj
-0.015 Tc 0.015 Tw (ng)Tj
0 Tc 0 Tw ( )Tj
1.734 0 Td
(r)Tj
0.318 0 Td
(e)Tj
-0.015 Tc 0.015 Tw 0.43 0 Td
(su)Tj
-0.014 Tc 0.014 Tw (lt)Tj
-0.015 Tc 0.015 Tw (s )Tj
0 Tc 0 Tw 1.996 0 Td
(a)Tj
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12.189 0 Td
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19.161 0 Td
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11.494 0 Td
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0 -1.2 Td
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5.972 0 Td
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(While not research-related, she said there is)Tj
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10.137 0 Td
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0.195 0 Td
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0 -1.2 Td
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0 -1.2 Td
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15.86 0 Td
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4.891 0 Td
(He is a primary care physician in)Tj
-4.891 -1.134 Td
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0 -1.2 Td
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1.8 -1.2 Td
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8.247 0 Td
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0 -1.2 Td
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0 -1.2 Td
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0 -1.2 Td
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(Australia-based system known as the Skin)Tj
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0 -1.2 Td
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0 -1.2 Td
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8.608 0 Td
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(\223Part of that is primarily letting practitioners)Tj
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0 -1.2 Td
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-0.01 Tc 0.01 Tw 0.241 0 Td
(phys)Tj
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( )Tj
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(D)Tj
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(e.)Tj
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1.8 -1.2 Td
(Y)Tj
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(et currentl)Tj
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(y)Tj
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(, he said, some primary care)Tj
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0 -1.2 Td
(identify cancerous lesions or to stratify patients by)Tj
0 -1.2 Td
(risk for purposes of referral to a specialist. )Tj
1.8 -1.2 Td
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(f)Tj
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-11.862 -1.2 Td
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2.861 0 Td
(. Blouin, but public awareness of NMSCs)Tj
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( )Tj
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ET
0 0 0 0 k
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36.762 36.954 209.072 267.298 re
f
q
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q
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Q
Q
BT
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q
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h
0.87 5.99 m
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S
Q
Q
BT
10 0 0 10 131.0117 40.4521 Tm
(r)Tj
ET
q
-27 0.952 774.761 1072.8 re
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h
S
Q
Q
BT
10 0 0 10 133.7617 40.4521 Tm
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ET
q
-27 0.952 774.761 1072.8 re
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h
S
Q
Q
BT
10 0 0 10 136.7617 40.4521 Tm
( )Tj
0.3 0 Td
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ET
q
-27 0.952 774.761 1072.8 re
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h
S
Q
Q
BT
10 0 0 10 147.7617 40.4521 Tm
(a)Tj
ET
q
-27 0.952 774.761 1072.8 re
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h
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h
S
Q
Q
BT
10 0 0 10 153.2617 40.4521 Tm
(r)Tj
ET
q
-27 0.952 774.761 1072.8 re
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0 0 0 1 K
0.24 w 4 M 0 j 0 J []0 d
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q 1 0 0 1 153.9922 40.4521 cm
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h
S
Q
Q
BT
10 0 0 10 157.0117 40.4521 Tm
(i)Tj
ET
q
-27 0.952 774.761 1072.8 re
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0 0 0 1 K
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h
-0.44 6.75 m
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h
S
Q
Q
BT
10 0 0 10 160.0117 40.4521 Tm
(e)Tj
ET
q
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h
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h
S
Q
Q
BT
10 0 0 10 165.2617 40.4521 Tm
(-)Tj
ET
0 0 0 1 K
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h
S
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BT
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10 0 0 10 169.2617 40.4521 Tm
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ET
q
-27 0.952 774.761 1072.8 re
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h
S
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BT
10 0 0 10 177.5117 40.4521 Tm
(i)Tj
ET
q
-27 0.952 774.761 1072.8 re
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h
S
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Q
BT
10 0 0 10 180.2617 40.4521 Tm
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ET
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h
S
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BT
10 0 0 10 185.5117 40.4521 Tm
(h)Tj
ET
q
-27 0.952 774.761 1072.8 re
W n
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h
S
Q
Q
BT
10 0 0 10 190.7617 40.4521 Tm
(\350)Tj
ET
q
-27 0.952 774.761 1072.8 re
W n
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h
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h
-3.271 4.67 m
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h
S
Q
Q
BT
10 0 0 10 196.0117 40.4521 Tm
(l)Tj
ET
/GS1 gs
q 1 0 0 1 196.7422 40.4521 cm
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0.88 7.1 l
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h
S
Q
BT
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10 0 0 10 199.0117 40.4521 Tm
(e)Tj
ET
q
-27 0.952 774.761 1072.8 re
W n
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q 1 0 0 1 203.6318 42.7119 cm
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h
S
Q
Q
BT
10 0 0 10 204.2617 40.4521 Tm
( )Tj
0.275 0 Td
(B)Tj
ET
q
-27 0.952 774.761 1072.8 re
W n
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h
0.87 6.04 m
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h
0.87 3.211 m
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h
S
Q
Q
BT
10 0 0 10 213.0117 40.4521 Tm
(l)Tj
ET
/GS1 gs
q 1 0 0 1 213.7422 40.4521 cm
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h
S
Q
BT
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10 0 0 10 216.0117 40.4521 Tm
(o)Tj
ET
q
-27 0.952 774.761 1072.8 re
W n
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S
Q
Q
BT
10 0 0 10 221.2617 40.4521 Tm
(u)Tj
ET
q
-27 0.952 774.761 1072.8 re
W n
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h
S
Q
Q
BT
10 0 0 10 226.5117 40.4521 Tm
(i)Tj
ET
q
-27 0.952 774.761 1072.8 re
W n
/GS1 gs
q 1 0 0 1 228.1221 40.4521 cm
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h
-0.44 6.75 m
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h
S
Q
Q
BT
10 0 0 10 229.5117 40.4521 Tm
(n)Tj
ET
q
-27 0.952 774.761 1072.8 re
W n
/GS1 gs
q 1 0 0 1 230.2422 40.4521 cm
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0.88 0 l
0.88 2.91 l
0.88 3.06 0.899 3.21 0.939 3.32 c
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